Axios CEO Jim VandeHei and his wife have spent years navigating hospitals and emergency rooms as she battles multiple chronic illnesses. The experience convinced him that too much of the American health system is failing the patients who need it most. Then they went to Mayo Clinic. Jim and Axios co-founder Mike Allen unpack what Mayo does differently, from coordinated care and doctor incentives to faster testing and AI, and which parts of its model could offer a better way forward for American medical systems.