In 2021, more than 10 million people fell ill from tuberculosis and 1.6 million people died. Effective vaccines would undoubtedly be the best solution to prevent and potentially eradicate TB. However, no new TB vaccine has been licensed in 100 years. The prospects for novel effective TB vaccines have improved recently, with at least 16 vaccine candidates under development. What mechanisms can accelerate development and deployment of safe and effective TB vaccines?