The strongest of all the Otsutsuki, Isshiki was introduced as the biggest known antagonist to date. Isshiki was higher ranking than Kaguya Otsutsuki, making him stronger than the latter, In his fight against Naruto Uzumaki and Sasuke Uchiha, Isshiki proved himself to be quite capable by defeating them both without so much as a scratch. With his ocular powers, he could shrink up himself and anything inanimate. He could also use his special Dojutsu power called Daikokuten to summon large cubes which could destroy anyone.